ENVIS NIOH : Bibliography : Asbestosis

Bibliography : Asbestosis

Author	Title	Year	Journal/Proceedings	Reftype	DOI/URL
Bhattacharjee P, Paul S, Bhattacharjee P	Risk of occupational exposure to asbestos, silicon and arsenic on pulmonary disorders: Understanding the genetic-epigenetic interplay and future prospects. [Abstract] [BibTeX]	2016	Environ Res. Vol. 147, pp. 425-34	article	DOI
Abstract: BACKGROUND: Epidemiological studies suggest strong association of lung disorders with occupational exposure to asbestos, silicon and arsenic. The chronic occupational exposure primarily through inhalation results in adverse outcome on the respiratory tract which may also be fatal. Although several mechanisms have attributed towards these diseases; the molecular pathogenesis is still unknown. OBJECTIVE: In this review, we investigated the plausible molecular mechanism based on current research that may identify the genetic and epigenetic susceptibility of respiratory disorders upon such occupational exposures in humans. METHODS: We considered genetic variants and epigenetic alterations associated with pulmonary exposure hazards leading to asbestosis, silicosis and arsenicosis. Our review is stringently based on the literatures available through peer-reviewed articles mostly published in the last 10 years. Relevant search were conducted using keywords like "occupational lung disorders" along with "asbestos", "silicon" and "arsenic". RESULTS: Till September 2015, pubmed search yielded approximately 780 articles relating to asbestos exposure; 240 articles for silicon exposure and 60 articles for arsenic exposure. Extensive screening for genetic and epigenetic factors identified certain genes and related pathways that are important to determine the susceptibility of an individual towards such occupational exposure. CONCLUSION: The link between genotype and phenotype and its association with disease susceptibility is very complex in nature due to several factors like person's environment, lifestyle and nutritional status. The epigenome is dynamic as well as reversible and can be reshaped further by certain dietary components throughout its life. In the present review, we have addressed the role of molecular pathogenesis of occupational lung diseases based on the genetic variability and epigenetic alterations and also attempted to highlight the promising aspect of dietary interventions to counter toxic outcomes upon occupational exposure to asbestos, silicon or arsenic.
BibTeX: @article{BhattacharjeeP2016, author = {Bhattacharjee P, Paul S, Bhattacharjee P}, title = {Risk of occupational exposure to asbestos, silicon and arsenic on pulmonary disorders: Understanding the genetic-epigenetic interplay and future prospects.}, journal = {Environ Res.}, year = {2016}, volume = {147}, pages = {425-34}, doi = {http://dx.doi.org/10.1016/j.envres.2016.02.038} }
Bhattacharya K, Dopp E, Kakkar P, Jaffery FN, Schiffmann D, Jaurand MC, Rahman I, Rahman Q	Biomarkers in risk assessment of asbestos exposure. [Abstract] [BibTeX]	2005	Mutat Res. Vol. 579(1-2), pp. 6-21	article
Abstract: Developments in the field of molecular epidemiology and toxicology have given valuable tools for early detection of impending disease or toxic condition. Morbidity due to respiratory distress, which may be due to environmental and occupational exposure, has drawn attention of researchers worldwide. Among the occupational exposure to respiratory distress factors, fibers and particles have been found to be main culprits in causing diseases like asbestosis, pleural plaques, mesotheliomas and bronchogenic carcinomas. An early detection of the magnitude of exposure or its' effect using molecular end points is of growing importance. The early inflammatory responses like release of the inflammatory cells collected by non-invasive methods give an indication of the unwanted exposure and susceptibility to further complications. Since free radicals like O2-, OH, OOH, NO, NOO, etc. are involved in the progression of asbestos-related diseases and lead to cytogenetic changes, an evaluation of antioxidant states reducing equivalents like GSH and ROS generation can be a good biomarker. The cytogenetic end points like chromosomal aberration, micronucleus formation and sister chromatid exchange give indication of genetic damage, hence they are used as effective biomarkers. New techniques like fluorimetric analysis of DNA unwinding, alkaline elution test, fluorescent in situ hybridization and comet assay are powerful tools for early detection of initiation of disease process and may help in planning strategies for minimizing morbidity related to asbestos fiber exposure. The present review article covers in detail possible biomarkers for risk assessment of morbidity due to fibers/particles in exposed population.
BibTeX: @article{BhattacharyaK2005, author = {Bhattacharya K, Dopp E, Kakkar P, Jaffery FN, Schiffmann D, Jaurand MC, Rahman I, Rahman Q}, title = {Biomarkers in risk assessment of asbestos exposure.}, journal = {Mutat Res.}, year = {2005}, volume = {579(1-2)}, pages = {6-21} }
Das B, Misra V, Viswanathan PN, Rahman Q	Lung mitochondria in experimental asbestosis [Abstract] [BibTeX]	1983	Environ Res. Vol. 31(2), pp. 390-8	article
Abstract: Alterations in lung mitochondria were followed in guinea pigs at different periods after a single intratracheal injection of chrysotile dust. Cytochrome c oxidase and succinic dehydrogenase activities showed gradual increase after 90 days, whereas monoamine oxidase remained unaffected throughout the study. There was an increase in glutamate dehydrogenase activity in postmitochondrial as well as in mitochondrial fractions, the latter being accompanied by decreased latency of the enzyme. Mitochondria from asbestotic lung appeared to be more swollen than in normal animals at and after 90 days of exposure. There were fluctuations in the contents of different phospholipids as a result of asbestosis. Beyond 90 days, collagen and mucopolysaccharides also increased. The results confirm the contention that pulmonary mitochondria are among the major target sites in asbestosis.
BibTeX: @article{DasB1983, author = {Das B, Misra V, Viswanathan PN, Rahman Q}, title = {Lung mitochondria in experimental asbestosis}, journal = {Environ Res.}, year = {1983}, volume = {31(2)}, pages = {390-8} }
Dave SK, Beckett WS	Occupational asbestos exposure and predictable asbestos-related diseases in India. [Abstract] [BibTeX]	2005	Am J Ind Med. Vol. 48(2), pp. 137-43	article	DOI
Abstract: BACKGROUND: India imports nearly 100,000 metric tons of asbestos per year, and small-scale asbestos (chrysotile and tremolite) mining and milling contributes nearly 5%-10% of the total national usage. The industry is relatively young, having started in the 1950s and 1960s. METHODS: Surveys of asbestos-exposed workers have identified significant occupational exposures, early pleural and parenchymal changes on chest radiograph, and decrements in lung function. RESULTS AND CONCLUSIONS: Based on knowledge of past and current exposures to asbestos in industry, we can predict a future occurrence of clinical asbestos-related diseases-pleural changes, pulmonary fibrosis, bronchogenic carcinoma, and diffuse malignant mesothelioma. These cases of asbestos related disease are expected to occur in asbestos exposed workers from mining, milling, and manufacturing as well as in those with secondary exposures to asbestos-containing materials, including construction and maintenance workers, users of asbestos-containing consumer products, and the occupants of asbestos-containing buildings.
BibTeX: @article{DaveSK2005, author = {Dave SK, Beckett WS}, title = {Occupational asbestos exposure and predictable asbestos-related diseases in India.}, journal = {Am J Ind Med.}, year = {2005}, volume = {48(2)}, pages = {137-43}, doi = {http://dx.doi.org/10.1002/ajim.20198} }
Davis C, Vijaykumar J, Lackovic M, Diaz JH	Asbestosis in Louisiana: a descriptive review and demographic analysis of hospitalizations for abestosis, 1999-2009. [Abstract] [BibTeX]	2011	J La State Med Soc. Vol. 163(6), pp. 336-41	article
Abstract: Asbestosis is a debilitating, chronic, lung disease with no known treatment and most commonly occurs among workers in certain occupational settings. As a condition highly associated with occupational exposure, its incidence has been affected by changes in industry standards. In particular, the bans on both production and new uses of asbestos fibers put in place during the past 20 to 30 years have significantly reduced occupational exposures. Despite these restrictions, asbestos can still be found in many products. Louisiana has more facilities that produce, process, or use asbestos than any other state in the US. Health outcomes associated with asbestos exposure include asbestosis, mesothelioma, and lung cancer. To evaluate the impact of asbestos exposure on Louisiana residents, Louisiana Hospital Inpatient Discharge Data (LAHIDD) from 1999-2009 was analyzed. Results indicate that asbestosis hospitalizations have remained steady over the 11-year period with approximately 295 cases per year. White males have the highest rates, and cases are clustered geographically. Overall, Louisiana's rate is significantly greater than the US rate (p < 0.0001).
BibTeX: @article{DavisC2011, author = {Davis C, Vijaykumar J, Lackovic M, Diaz JH}, title = {Asbestosis in Louisiana: a descriptive review and demographic analysis of hospitalizations for abestosis, 1999-2009.}, journal = {J La State Med Soc.}, year = {2011}, volume = {163(6)}, pages = {336-41} }
Sharma DC	Indian groups demand ban on asbestos. [BibTeX]	2002	Lancet. Vol. 359(9315)	article	DOI
BibTeX: @article{DC2002, author = {Sharma DC}, title = {Indian groups demand ban on asbestos.}, journal = {Lancet.}, year = {2002}, volume = {359(9315)}, doi = {http://dx.doi.org/10.1016/S0140-6736(02)08400-3} }
Desai R, Hext P, Richards R	The prevention of asbestos-induced hemolysis. [BibTeX]	1975	Life Sci. Vol. 16(12), pp. 1931-8	article
BibTeX: @article{DesaiR1975, author = {Desai R, Hext P, Richards R}, title = {The prevention of asbestos-induced hemolysis.}, journal = {Life Sci.}, year = {1975}, volume = {16(12)}, pages = {1931-8} }
Fatma N, Jain AK, Rahman Q	Frequency of sister chromatid exchange and chromosomal aberrations in asbestos cement workers [Abstract] [BibTeX]	1991	Br J Ind Med. Vol. 48(2), pp. 103-5	article
Abstract: Exposure to asbestos minerals has been associated with a wide variety of adverse health effects including lung cancer, pleural mesothelioma, and cancer of other organs. It was shown previously that asbestos samples collected from a local asbestos factory enhanced sister chromatid exchanges (SCEs) and chromosomal aberrations in vitro using human lymphocytes. In the present study, 22 workers from the same factory and 12 controls were further investigated. Controls were matched for age, sex, and socioeconomic state. The peripheral blood lymphocytes were cultured and harvested at 48 hours for studies of chromosomal aberrations and at 72 hours for SCE frequency determinations. Asbestos workers had a raised mean SCE rate and increased numbers of chromosomal aberrations compared with a control population. Most of the chromosomal aberrations were chromatid gap and break types.
BibTeX: @article{FatmaN1991, author = {Fatma N, Jain AK, Rahman Q}, title = {Frequency of sister chromatid exchange and chromosomal aberrations in asbestos cement workers}, journal = {Br J Ind Med.}, year = {1991}, volume = {48(2)}, pages = {103-5} }
Frost JK, Gupta PK, Erozan YS, Carter D, Hollander DH, Levin ML, Ball WC Jr	Pulmonary cytologic alterations in toxic environmental inhalation. [BibTeX]	1973	Hum Pathol. Vol. 4(4), pp. 521-36	article
BibTeX: @article{FrostJK1973, author = {Frost JK, Gupta PK, Erozan YS, Carter D, Hollander DH, Levin ML, Ball WC Jr}, title = {Pulmonary cytologic alterations in toxic environmental inhalation.}, journal = {Hum Pathol.}, year = {1973}, volume = {4(4)}, pages = {521-36} }
Gothi D, Gahlot T, Sah RB, Saxena M, Ojha UC, Verma AK, Spalgais S	Asbestos-induced lung disease in small-scale clutch manufacturing workers. [Abstract] [BibTeX]	2016	Indian J Occup Environ Med. Vol. 20(2), pp. 95-102	article	DOI
Abstract: BACKGROUND: The crocidolite variety of asbestos is banned. However, chrysotile, which is not prohibited, is still used in developing countries in making products such as clutch plate. Fourteen workers from a small-scale clutch plate-manufacturing factory were analyzed for asbestos-induced lung disease as one of their colleagues had expired due to asbestosis. AIMS: This study was conducted to evaluate the awareness of workers, the prevalence and type of asbestos-induced lung disease, and the sensitivity and specificity of diffusion test. MATERIALS AND METHODS: History, examination, chest radiograph, spirometry with diffusion, and high resolution computed tomography (HRCT) thorax was performed in all the workers. The diagnosis of asbestos-induced lung disease was suspected on the basis of HRCT. This was subsequently confirmed on transbronchial lung biopsy (TBLB). RESULTS: None of the workers had detailed information about asbestos and its ill effects. Eleven out of 14 (71.42%) workers had asbestos-induced lung disease. All 11 had small airway disease (SAD). Three had SAD alone, 6 had additional interstitial lung disease (ILD), and 2 patients had additional ILD and chronic obstructive pulmonary disease. Sensitivity and specificity of residual volume (RV) or total lung capacity (TLC) for detecting SAD was 90% and 100%, respectively, and that of diffusion capacity of lung for carbon monoxide (DLCO) for detecting ILD was 100%. CONCLUSION: The awareness about asbestos in small-scale clutch-plate manufacturing industry is poor. The usage of chrysotile should be strictly regulated as morbidity and mortality is high. DLCO and RV/TLC are sensitive and specific in detecting nonmalignant asbestos induced lung disease.
BibTeX: @article{GothiD2016, author = {Gothi D, Gahlot T, Sah RB, Saxena M, Ojha UC, Verma AK, Spalgais S}, title = {Asbestos-induced lung disease in small-scale clutch manufacturing workers.}, journal = {Indian J Occup Environ Med.}, year = {2016}, volume = {20(2)}, pages = {95-102}, doi = {http://dx.doi.org/10.4103/0019-5278.197533} }
Gupta PK, Frost JK	Cytologic changes associated with asbestos exposure [BibTeX]	1981	Semin Oncol. Vol. 8(3), pp. 283-9	article
BibTeX: @article{GuptaPK1981, author = {Gupta PK, Frost JK}, title = {Cytologic changes associated with asbestos exposure}, journal = {Semin Oncol.}, year = {1981}, volume = {8(3)}, pages = {283-9} }
Jadhav AV, Roy N	Asbestosis: Past voices from the Mumbai factory floor. [Abstract] [BibTeX]	2012	Indian J Occup Environ Med. Vol. 16(3), pp. 131-6	article	DOI
Abstract: BACKGROUND: Asbestos's production, processing, and consumption is on very high scale in India and it is increasing, and so do the related diseases. Asbestosis is such a disease which causes progressive respiratory disability. AIM: To find out perceptions and thinking about this disease and its risk among the patients which will help in constructing an effective community-based prevention and rehabilitation program. MATERIALS AND METHODS: It was a community-based, qualitative study using a semi-structured interview schedule with 17 asbestosis patients from Mumbai, disgnosed by specialist with pulmonary function test and X-rays as per International Labour Organisation's recommandations. RESULTS: The risk percived by the patients is very less and attitude toward the illness is bengine as there is no clear understanding about the causation. The prolong latent period appears to be the main cause. It suggests a need of very strong program for prevention of asbestosis with the incorporation of worker awareness and eduaction for safety. The socio-economical status and educational levels of the workers make this floating population more vulnarable for manipulation by the corporates. CONCLUSION: Apart from the radical step of ban on asbestos, there is a need of community-based sustainable, affordable, and accessible rehabilitation program with a component of palliative care which will consider the different needs of this marginalized group. The need for such a program is intense as the number of asbestisis patients will keep on increasing till 30 to 40 years of asbestos ban.
BibTeX: @article{JadhavAV2012, author = {Jadhav AV, Roy N}, title = {Asbestosis: Past voices from the Mumbai factory floor.}, journal = {Indian J Occup Environ Med.}, year = {2012}, volume = {16(3)}, pages = {131-6}, doi = {http://dx.doi.org/10.4103/0019-5278.111758} }
Jindal SK, Aggarwal AN, Gupta D	Dust-induced interstitial lung disease in the tropics [Abstract] [BibTeX]	2001	Curr Opin Pulm Med. Vol. 7(5), pp. 272-7	article
Abstract: Inhalation of dusts is an important cause of interstitial lung disease in the tropical countries such as India. While dusts of organic origin, such as the cotton dust causing byssinosis, generally cause bronchial or bronchiolar involvement and hypersensitivity pneumonitis, inorganic metallic dusts cause progressive pulmonary fibrosis. Silicosis, coal workers' pneumoconiosis, and asbestosis are the three most commonly recognized forms of pneumoconiotic pulmonary fibrosis. Pulmonary tuberculosis is an important complication seen in up to 50% of patients of silicosis in some reports from India. The presentation is generally chronic, although acute and accelerated forms of silicosis are known when the exposures are heavy. Breathlessness, dry cough, and general constitutional symptoms are commonly seen. Patients with silicotuberculosis or other forms of infection may also have significant expectoration, hemoptysis, fever, and rapid progression. Respiratory failure and chronic cor pulmonale occur in the later stages. The diagnosis is easily established if the occupational history is available. Dense nodular opacities on chest roentgenograms, which may be large in patients with massive pulmonary fibrosis, are characteristic. Emphysematous changes generally appear in advanced stages or in patients who smoke. Bronchoalveolar lavage and/or lung biopsy may occasionally be required to establish or exclude other causes of interstitial lung disease. Treatment is largely palliative, although a variety of drugs including corticosteroids and procedures such as whole lung lavage have been tried. None of these methods has yet been found successful in the treatment. Preventive safety steps, including removal of the patient from the site of exposure, are the only effective strategies to control disease progression.
BibTeX: @article{JindalSK2001, author = {Jindal SK, Aggarwal AN, Gupta D}, title = {Dust-induced interstitial lung disease in the tropics}, journal = {Curr Opin Pulm Med.}, year = {2001}, volume = {7(5)}, pages = {272-7} }
Joshi TK, Gupta RK	Asbestos in developing countries: magnitude of risk and its practical implications. [Abstract] [BibTeX]	2004	Int J Occup Med Environ Health. Vol. 17(1), pp. 179-85	article
Abstract: In developing countries, aggressive marketing of chrysotile asbestos continues as a result of restrictions on its use being imposed by the developed countries. In the Asian continent, China and India are emerging as the major users of asbestos. There is enough evidence to link chrysotile with pulmonary fibrosis and lung cancer in humans, even at low levels of exposure, hence the need to apply the Precautionary Principle for phasing out its use globally. Due to poor occupational health and safety systems in developing countries and difficulties in early detection of pulmonary malignancy related to asbestos, the statistics remain sketchy. This is hampering efforts to create pressure on policy makers and to counter the propaganda of the asbestos industry. The International Labour Office believes that more than 100,000 deaths a year occur from asbestos-related disease. In the view of studies published in Europe and Australia, the number of deaths due to such malignancies will peak around the year 2020 and could be anywhere between half a million to a million. That means more than a million deaths will occur in developing countries. At about the same time when asbestos-related deaths start to decrease in developed countries, their number will begin to rise in developing countries. This presents a major challenge to the international scientific
BibTeX: @article{JoshiTK2004, author = {Joshi TK, Gupta RK}, title = {Asbestos in developing countries: magnitude of risk and its practical implications.}, journal = {Int J Occup Med Environ Health.}, year = {2004}, volume = {17(1)}, pages = {179-85} }
Kern DG, Patel SR	Auscultated forced expiratory time as a clinical and epidemiologic test of airway obstruction [Abstract] [BibTeX]	1991	Chest. Vol. 100(3), pp. 636-9	article
Abstract: OBJECTIVE: Seeking an inexpensive, readily available, clinical, screening, and field surveillance test of airway obstruction, we determined the validity of current dogma that forced expiratory time (FET) is a good clinical test of airway obstruction yet is of no epidemiologic use given excessive intrasubject variability. SUBJECTS AND METHODS: Two hundred twenty-nine white male plumbers and pipefitters were evaluated by spirometry, chest roentgenography, and a standardized respiratory questionnaire during a union-sponsored asbestos screening program. Subjects were classified as having large airway obstruction (LAO), small airway obstruction (SAO) alone, or no obstruction, on the basis of standard spirometric prediction equations. Two physicians, blinded to clinical and spirometric data, independently measured FET while auscultating the trachea with a stethoscope. The FET was defined as the time taken for an individual to forcefully exhale through an open mouth from total lung capacity until airflow became inaudible. Five such times were recorded for each subject. The mean of the three times having the narrowest range was deemed the FET for calculating test sensitivity and specificity. Based on previous literature, an FET greater than or equal to 6 s was considered abnormally prolonged. RESULTS: Two hundred five subjects completed both spirometry and FET testing; 67 had LAO, 5 SAO, and 133 no obstruction. A total of 83 percent had three FETs reproducible within a range of less than or equal to 1 s. The sensitivity and specificity of FET for LAO were 92 and 43 percent, respectively, while for SAO alone, 60 and 44 percent, respectively. Overall, FET misclassified 56 percent of nonobstructed subjects. Adjusting the normal-abnormal cutoff points for both FET and SAO minimally improved the performance of FET. CONCLUSION: Although FET is a simple, inexpensive, sensitive, and fairly reproducible clinical test of LAO, it cannot be recommended as a clinical or an epidemiologic tool because of its extremely low specificity.
BibTeX: @article{KernDG1991, author = {Kern DG, Patel SR}, title = {Auscultated forced expiratory time as a clinical and epidemiologic test of airway obstruction}, journal = {Chest.}, year = {1991}, volume = {100(3)}, pages = {636-9} }
Mann B, Sinha CN	Jack needle lung biopsy in pneumoconiosis. [BibTeX]	1966	Dis Chest. Vol. 50(5), pp. 504-8	article
BibTeX: @article{MannB1966, author = {Mann B, Sinha CN}, title = {Jack needle lung biopsy in pneumoconiosis.}, journal = {Dis Chest.}, year = {1966}, volume = {50(5)}, pages = {504-8} }
Mukherjee AK, Rajmohan HR, Dave SK, Rajan BK, Kakde Y, Rao SR	An environmental survey in chrysotile asbestos milling processes in India. [Abstract] [BibTeX]	1992	Am J Ind Med. Vol. 22(4)	article
Abstract: Environmental monitoring to determine airborne asbestos fiber levels has been carried out in four different mills processing chrysotile asbestos in the Cuddapah District (Andhra Pradesh) of India. The "membrane filter method" comprising standard asbestos sampling techniques, acetone-triacetin method for sample preparation, fiber counting, and sizing using the phase contrast optical microscope were adopted in the study. Fiber concentrations both with respect to personal exposures and processing areas were found in most of the cases to be much higher than the prescribed Threshold Limit Value (TLVs) of the developed and developing countries for chrysotile asbestos. By optical microscopy, fiber length distribution showed 70% of fibers in the milling processes were in size range > 5-10 microns, whereas in > 10-20 and > 20 microns, 20% and 8%, respectively. Fiber identification for major elemental content, also done by using scanning electron microscope equipped with an energy dispersive X-ray analyzer, indicated the presence of tremolite along with chrysotile. The study stresses the urgent need to adopt suitable engineering controls at the dust generating sources to reduce the fiber level in the mill environment below the threshold limit.
BibTeX: @article{MukherjeeAK1992, author = {Mukherjee AK, Rajmohan HR, Dave SK, Rajan BK, Kakde Y, Rao SR}, title = {An environmental survey in chrysotile asbestos milling processes in India.}, journal = {Am J Ind Med.}, year = {1992}, volume = {22(4)} }
Mukherjee S, de Klerk N, Palmer LJ, Olsen NJ, Pang SC, William Musk A	Chest pain in asbestos-exposed individuals with benign pleural and parenchymal disease. [Abstract] [BibTeX]	2000	Am J Respir Crit Care Med. Vol. 162(5), pp. 1807-11	article	DOI
Abstract: Many asbestos-exposed individuals complain of chest pain for which there is no clear explanation. To determine whether chest pain is associated with the presence of benign pleural or parenchymal disease on chest radiograph, we studied 1,280 subjects undergoing surveillance because of prior asbestos exposure at Wittenoom, Western Australia. All subjects completed the Rose questionnaire on chest pain and this revealed 556 subjects (43%) who experienced some chest pain. A posterior-anterior chest radiograph was performed at the same clinic visit and was subsequently graded independently by two experienced readers for diffuse parenchymal disease and pleural disease. Logistic regression models adjusted for sex, age, and cumulative asbestos exposure indicated that the presence of chest pain was significantly associated with the presence of both benign pleural disease and diffuse parenchymal disease. Further analysis after stratification of chest pain into nonanginal and anginal pain showed that there was a significant association between anginal pain and the presence of pleural and parenchymal asbestos-induced radiologic abnormalities and an association of nonanginal pain with parenchymal disease. We conclude that radiographic evidence of either parenchymal or pleural disease in subjects exposed to asbestos is significantly related to the presence of chest pain, particularly anginal pain.
BibTeX: @article{MukherjeeS2000, author = {Mukherjee S, de Klerk N, Palmer LJ, Olsen NJ, Pang SC, William Musk A}, title = {Chest pain in asbestos-exposed individuals with benign pleural and parenchymal disease.}, journal = {Am J Respir Crit Care Med.}, year = {2000}, volume = {162(5)}, pages = {1807-11}, doi = {http://dx.doi.org/10.1164/ajrccm.162.5.9912012} }
Mulay SR, Kulkarni OP, Rupanagudi KV, Migliorini A, Darisipudi MN, Vilaysane A, Muruve D, Shi Y, Munro F, Liapis H, Anders HJ	Calcium oxalate crystals induce renal inflammation by NLRP3-mediated IL-1? secretion. [Abstract] [BibTeX]	2013	J Clin Invest. Vol. 123(1), pp. 236-46	article
Abstract: Nephrocalcinosis, acute calcium oxalate (CaOx) nephropathy, and renal stone disease can lead to inflammation and subsequent renal failure, but the underlying pathological mechanisms remain elusive. Other crystallopathies, such as gout, atherosclerosis, and asbestosis, trigger inflammation and tissue remodeling by inducing IL-1? secretion, leading us to hypothesize that CaOx crystals may induce inflammation in a similar manner. In mice, intrarenal CaOx deposition induced tubular damage, cytokine expression, neutrophil recruitment, and renal failure. We found that CaOx crystals activated murine renal DCs to secrete IL-1? through a pathway that included NLRP3, ASC, and caspase-1. Despite a similar amount of crystal deposits, intrarenal inflammation, tubular damage, and renal dysfunction were abrogated in mice deficient in MyD88; NLRP3, ASC, and caspase-1; IL-1R; or IL-18. Nephropathy was attenuated by DC depletion, ATP depletion, or therapeutic IL-1 antagonism. These data demonstrated that CaOx crystals trigger IL-1?-dependent innate immunity via the NLRP3/ASC/caspase-1 axis in intrarenal mononuclear phagocytes and directly damage tubular cells, leading to the release of the NLRP3 agonist ATP. Furthermore, these results suggest that IL-1? blockade may prevent renal damage in nephrocalcinosis.
BibTeX: @article{MulaySR2013, author = {Mulay SR, Kulkarni OP, Rupanagudi KV, Migliorini A, Darisipudi MN, Vilaysane A, Muruve D, Shi Y, Munro F, Liapis H, Anders HJ}, title = {Calcium oxalate crystals induce renal inflammation by NLRP3-mediated IL-1? secretion.}, journal = {J Clin Invest.}, year = {2013}, volume = {123(1)}, pages = {236-46} }
Nair P, Rupawate RU, Prabhakaran LC, Bijur S, Kamat SR	Evaluating computed tomography and broncho alveolar lavage in early diagnosis of pulmonary asbestosis. [Abstract] [BibTeX]	1991	Sarcoidosis. Vol. 8(2), pp. 115-9	article
Abstract: Forty-eight male asbestos workers were studied with clinical interrogation and examination, chest radiograph, lung function, body box studies, blood gases at rest and after exercise, BAL and in 40 cases by CT scan. Mean age was 40:1 (+/- 5.2) and work exposure 18.1 (+/- 4.0) years. There were 52% smokers. We found rales in 93%. Lung functions and clinical picture were not related to smoking (FEV1 was lower). There was evidence of airway obstruction by FEV1/FVC% (58% as below 80%), bronchodilator improvement (18% as over 10%), Raw (45% as over 2 cm H2O/l/sec) or RV/TLC% (39.5% as above 40%). Arterial pO2 decreased (over 2 mm) on exercise in 18%. By ILO classification chest radiographs were up to 1/1 in 10 (21%) and 2/2 or above in 19 (40%). Pleural abnormalities were seen by X-ray in 20 (42%) and by CT Scan in 26 (54%). The scan was abnormal in 92%. Lung function was not related to radiographic ILO grading but was lower with abnormal CT scan. BAL revealed normal (or low) cell counts, fewer macrophages (35%) and more polymorphs (23%) and lymphocytes (29%) over values for controls reported earlier (8); only 9 (19%) showed high cell counts. Asbestos body count was high (28.4) and was unrelated to other abnormalities. In some departments asbestos (respirable) fibre load was high (mean 0.61 to 3.12: maximum 0.84 to 6.78). It is concluded that in a proportion, early asbestosis can be diagnosed by CT scanning and high asbestos body count in BAL.
BibTeX: @article{NairP1991, author = {Nair P, Rupawate RU, Prabhakaran LC, Bijur S, Kamat SR}, title = {Evaluating computed tomography and broncho alveolar lavage in early diagnosis of pulmonary asbestosis.}, journal = {Sarcoidosis.}, year = {1991}, volume = {8(2)}, pages = {115-9} }
Narang S, Kaw JL, Zaidi SH	Formation of asbestos bodies under the influence of parenteral iron overload. [Abstract] [BibTeX]	1978	Acta Pharmacol Toxicol (Copenh). Vol. 42(5), pp. 337-42	article
Abstract: The effect of parenteral administration of iron (dextran) on the number of asbestos fibers in the lungs, formation of asbestos bodies and the development of interstitial fibrosis was studied in guinea pigs exposed intratracheally to anthophyllite dust. The treatment did not accelerate, either qualitatively or quantitatively, the formation of asbestos bodies or retard the development of interstitial fibrosis. The number of naked asbestos fibers was also similar in anthophyllite-inoculated animals to those similarly inoculated, but having had, additionally, a previous saturation with iron.
BibTeX: @article{NarangS1978, author = {Narang S, Kaw JL, Zaidi SH}, title = {Formation of asbestos bodies under the influence of parenteral iron overload.}, journal = {Acta Pharmacol Toxicol (Copenh).}, year = {1978}, volume = {42(5)}, pages = {337-42} }
Naraynsingh V, Ramdass MJ, Lum CL	Malignant peritoneal mesothelioma presenting as recurrent adhesion obstruction in general surgery: a case report. [Abstract] [BibTeX]	2011	J Med Case Rep. Vol. 30(5)	article
Abstract: Malignant peritoneal mesothelioma is a well-described entity in many reports in the literature in which it has been associated with asbestosis. However, there is no information describing the gross appearance and cardinal features seen during laparotomy, hence it is easy for the unwary surgeon to miss the diagnosis of this rare condition. CASE PRESENTATION: A 49-year-old man of African descent presented to our hospital with a three-month history of weight loss, anorexia, abdominal distension, and general signs of cachexia and ascites on second presentation. At first presentation one year prior to this, he had undergone a laparotomy at our institution by a different team for intestinal obstruction secondary to adhesions with no biopsy taken. The patient's condition subsequently progressively deteriorated, and investigations including upper and lower gastrointestinal endoscopies and computed tomography of the abdomen were inconclusive, except for some free fluid in the peritoneal cavity and diffuse, mild thickening of the gut wall and mesentery. A second-look exploratory laparotomy revealed widespread nodular thickening of the visceral peritoneum with a striking, uniformly diffuse, erythematous, and velvety appearance. The peritoneal biopsy histology showed that the patient had malignant peritoneal mesothelioma. His condition deteriorated rapidly, and he died eight weeks after surgery. CONCLUSION: Our report aims to increase the diagnosing clinician's awareness of the cardinal features of malignant peritoneal mesothelioma and thus reduce diagnostic errors and delays in treatment.
BibTeX: @article{NaraynsinghV2011, author = {Naraynsingh V, Ramdass MJ, Lum CL}, title = {Malignant peritoneal mesothelioma presenting as recurrent adhesion obstruction in general surgery: a case report.}, journal = {J Med Case Rep.}, year = {2011}, volume = {30}, number = {5} }
Nigam SK, Suthar AM, Patel MM, Karnik AB, Dave SK, Kashyap SK, Venkaiah K	Humoral immunological profile of workers exposed to asbestos in asbestos mines [Abstract] [BibTeX]	1993	Indian J Med Res. Vol. 98, pp. 274-7	article
Abstract: Humoral immunological profile including immunoglobulins IgG, IgA, IgM, C-reactive protein, rheumatoid factor, antinuclear antibodies and circulating immune complexes were studied in a representative sample of 36 workers suffering from asbestosis (group A), 35 workers who are exposed to asbestos but not having evidence of asbestosis (group B) and 28 control workers (group C). Mean IgG and IgA levels were found to be significantly higher in the two exposed groups than in the controls. Circulating immune complexes of IgG, IgA and IgM class were detected in a significant percentage of cases in exposed groups than in controls. In groups A and B, the percentage of positive ANF cases was much higher than in the controls. The results suggest that immunological changes are associated with exposure to asbestos and these may play an important role in the pathogenesis of the disease process.
BibTeX: @article{NigamSK1993, author = {Nigam SK, Suthar AM, Patel MM, Karnik AB, Dave SK, Kashyap SK, Venkaiah K}, title = {Humoral immunological profile of workers exposed to asbestos in asbestos mines}, journal = {Indian J Med Res.}, year = {1993}, volume = {98}, pages = {274-7} }
Rahman Q, Das B, Viswanathan PN	Biochemical mechanisms in asbestos toxicity [Abstract] [BibTeX]	1983	Environ Health Perspect. Vol. 51, pp. 299-303	article
Abstract: The alarming hazardous nature of asbestos makes it the foremost among toxic fugitive dusts. The biochemical mechanisms responsible for the diverse biological effects of asbestos, such as fibrosis, asbestos bodies, pleural plaques, respiratory difficulty, cancer, and cytotoxicity, are being studied in this laboratory. As asbestosis progresses in guinea pigs, along with reticulum formation, lysosomal enzymes are released from membrane-bound latent state to active free form, initiating degradative changes. Considerable alterations take place in the pulmonary metabolic machinery. Mitochondria in lung cells were found to be important loci for the toxic effect of asbestos. A profile of mitochondrial activity, in control and asbestotic animals, revealed specific enzymic changes such as increased cytochrome c oxidase during the disease. The functional organization of mitochondria was also altered, since the organelles from asbestotic lungs were swollen as measured by spectrophotometry. Glutamate dehydrogenase activity of mitochondria became exposed in asbestosis. The maleate dehydrogenase shunt which is involved in transport of the redox potential across the membrane was enhanced in cytosol and mitochondria. The involvement of microsomal enzymes in asbestosis was indicated by alterations in glucose-6-phosphatase and tyrosine transaminase and aniline hydroxylase. Changes in the biotransformational capacity of lung, due to asbestos, could be an important aspect in toxicity, especially the carcinogenic effect. Considerable alterations were encountered in the levels of different phospholipids and in mucopolysaccharide constituents. On the basis of the above, the molecular mechanisms in asbestos toxicity are explained as an integrated model. Interactions of dust constituents with those of membranes and the ensuing metabolic adjustments are thus important in the etiology of asbestosis.
BibTeX: @article{RahmanQ1983, author = {Rahman Q, Das B, Viswanathan PN}, title = {Biochemical mechanisms in asbestos toxicity}, journal = {Environ Health Perspect.}, year = {1983}, volume = {51}, pages = {299-303} }
Ramanathan AL, Subramanian V	Present status of asbestos mining and related health problems in India--a survey [Abstract] [BibTeX]	2001	Ind Health. Vol. 39(4), pp. 309-15	article
Abstract: At present in India more than thirty mines are in operation. It produces 2800 tones of asbestos per month (mainly chrysotile and tremolite) and in recent years substantial quantity (-70%) is imported from Canada. The quality of asbestos produced in India is very poor. The mining and milling and other related processes expose the people to cancer and related diseases. Women are more affected by their exposure in processing unit compared to male who are generally working in mines. Direct and indirect employment in asbestos related industry and mine is around 100,000 workers. Latency period (length of the time between exposure and the onset of diseases) in India is estimated to be 20-37 yr. The causes for lung and breathing problem are mainly due to obsolete technology and direct contact with the asbestos products without proper precaution, because in India asbestos are sold without statutory warning. This paper reviews health effects (such as fibrosis, sequelae, bronchogenic cancer, and malignant mesothelioma) on the Indian mine workers caused due to asbestos mining related activities with respect to their present day condition.
BibTeX: @article{RamanathanAL2001, author = {Ramanathan AL, Subramanian V}, title = {Present status of asbestos mining and related health problems in India--a survey}, journal = {Ind Health.}, year = {2001}, volume = {39(4)}, pages = {309-15} }
Chaturvedi S	Carcinogenicity of asbestos: convincing evidence, conflicting interests. [Abstract] [BibTeX]	2001	Natl Med J India. Vol. 14(1), pp. 43-6	article
Abstract: In spite of hard epidemiological and clinical evidence associating asbestos fibre with asbestosis and cancer, the issue is controversial and likely to remain so. The focus is now shifting to non-occupational exposure, differential risk to various asbestos fibre types and the relatively low level of carinogenicity of the chrysotile form. This creates further space for scientific debate and the opportunity to form a considered opinion. However, the situation may take a worrisome turn if some of these scientific inquiries are used by market forces to their advantage. A look at the history of corporate activities in asbestos-related research reveals a disturbing trend. Information that was made available, through legal interventions, clearly shows how for half a century the asbestos industry in collaboration with some academic leaders of occupational medicine successfully suppressed evidence against asbestos. In developing countries, extensive and aggressive marketing continues by chrysotile producers, mainly Canadian companies. There is renewed pressure on this part of the world since new use of asbestos has been almost completely discontinued in the developed countries as a result of public pressure and state prohibitions. In this scenario, relaxation of public health control over any form of asbestos should be opposed. It is extremely dangerous and scientifically untenable to say that chrysotile asbestos can be used without risk. It has been identified as a potent human carcinogen, and remains so. However, some restraint must be exercised while dealing with asbestos that has already been released into the environment. Disturbing it unnecessarily may cause more harm than good.
BibTeX: @article{S2001, author = {Chaturvedi S}, title = {Carcinogenicity of asbestos: convincing evidence, conflicting interests.}, journal = {Natl Med J India.}, year = {2001}, volume = {14(1)}, pages = {43-6} }
Kapoor S	Claudin-7 expression and its association with tumor progression in systemic malignancies. [BibTeX]	2013	Hum Pathol. Vol. 44(9), pp. 1957-8	article	DOI
BibTeX: @article{S2013, author = {Kapoor S}, title = {Claudin-7 expression and its association with tumor progression in systemic malignancies.}, journal = {Hum Pathol.}, year = {2013}, volume = {44(9)}, pages = {1957-8}, doi = {http://dx.doi.org/10.1016/j.humpath.2013.04.022} }
Sahu AP, Shanker R, Zaidi SH	Early changes in lymph nodes of mice after intraperitoneal injection of asbestos. [BibTeX]	1978	Indian J Exp Biol. Vol. 16(9), pp. 976-9	article
BibTeX: @article{SahuAP1978, author = {Sahu AP, Shanker R, Zaidi SH}, title = {Early changes in lymph nodes of mice after intraperitoneal injection of asbestos.}, journal = {Indian J Exp Biol.}, year = {1978}, volume = {16(9)}, pages = {976-9} }
Saiyed HN, Tiwari RR	Occupational health research in India. [Abstract] [BibTeX]	2004	Ind Health. Vol. 42(2), pp. 141-8	article
Abstract: India being a developing nation is faced with traditional public health problems like communicable diseases, malnutrition, poor environmental sanitation and inadequate medical care. However, globalization and rapid industrial growth in the last few years has resulted in emergence of occupational health related issues. Agriculture (cultivators i.e. land owners + agriculture labourers) is the main occupation in India giving employment to about 58% of the people. The major occupational diseases/morbidity of concern in India are silicosis, musculo-skeletal injuries, coal workers' pneumoconiosis, chronic obstructive lung diseases, asbestosis, byssinosis, pesticide poisoning and noise induced hearing loss. There are many agencies like National Institute of Occupational Health, Industrial Toxicology Research Centre, Central Labour Institute, etc. are working on researchable issues like Asbestos and asbestos related diseases, Pesticide poisoning, Silica related diseases other than silicosis and Musculoskeletal disorders. Still much more is to be done for improving the occupational health research. The measures such as creation of advanced research facilities, human resources development, creation of environmental and occupational health cells and development of database and information system should be taken.
BibTeX: @article{SaiyedHN2004, author = {Saiyed HN, Tiwari RR}, title = {Occupational health research in India.}, journal = {Ind Health.}, year = {2004}, volume = {42(2)}, pages = {141-8} }
Saxena KC, Srivastava L, Ali S, Dogra RK	Pleural plaques in asbestosis: effect of Candida albicans. [Abstract] [BibTeX]	1982	Toxicol Lett. Vol. 13(3-4), pp. 175-8	article
Abstract: Effect of chrysotile dust alone or together with Candida albicans administered intratracheally in guinea pigs was studied in the genesis of pleural plaques over a period of 12 months. A significant increase of mucopolysaccharides, phosphorus, calcium and -SH content was detected in pleural fluid of animals treated with chrysotile and Candida albicans together than in those treated with chrysotile or Candida albicans alone. The results suggest that an infection of Candida albicans accentuates the effect of chrysotile by altering the biochemical parameters preceding to the formation of pleural plaques.
BibTeX: @article{SaxenaKC1982, author = {Saxena KC, Srivastava L, Ali S, Dogra RK}, title = {Pleural plaques in asbestosis: effect of Candida albicans.}, journal = {Toxicol Lett.}, year = {1982}, volume = {13(3-4)}, pages = {175-8} }
Sayan M, Shukla A, MacPherson MB, Macura SL, Hillegass JM, Perkins TN, Thompson JK, Beuschel SL, Miller JM, Mossman BT	Extracellular signal-regulated kinase 5 and cyclic AMP response element binding protein are novel pathways inhibited by vandetanib (ZD6474) and doxorubicin in mesotheliomas. [Abstract] [BibTeX]	2014	Am J Respir Cell Mol Biol. Vol. 51(5), pp. 595-603	article	DOI
Abstract: Malignant mesothelioma (MM), lung cancers, and asbestosis are hyperproliferative diseases associated with exposures to asbestos. All have a poor prognosis; thus, the need to develop novel and effective therapies is urgent. Vandetanib (Van) (ZD6474, ZACTIMA) is a tyrosine kinase inhibitor that has shown equivocal results in clinical trials for advanced non-small cell lung cancer. However, tyrosine kinase inhibitors alone have shown no significant clinical activity in phase II trials of patients with unresectable MM. Using epithelioid (HMESO) and sarcomatoid (H2373) human MM lines, the efficacy of tumor cell killing and signaling pathways modulated by Van with and without doxorubicin (Dox) was examined. Van alone reduced total cell numbers in HMESO MM and synergistically increased the toxicity of Dox in HMESO and H2373 cells. Most importantly, we identified two novel cell survival/resistance pathways, ERK5 and cyclic AMP response element binding protein (CREB), that were inhibited by Van and Dox. After silencing of either ERK5 or CREB, significant decreases in cell numbers in the Dox-resistant sarcomatoid H2373 line were observed. Results suggest that a plethora of cell signaling pathways associated with cell survival are induced by Dox but inhibited by the addition of Van in MM. Data from our study support the combined efficacy of Van and Dox as a novel approach in the treatment of MM that is further enhanced by blocking ERK5 or CREB signaling cascades.
BibTeX: @article{SayanM2014, author = {Sayan M, Shukla A, MacPherson MB, Macura SL, Hillegass JM, Perkins TN, Thompson JK, Beuschel SL, Miller JM, Mossman BT}, title = {Extracellular signal-regulated kinase 5 and cyclic AMP response element binding protein are novel pathways inhibited by vandetanib (ZD6474) and doxorubicin in mesotheliomas.}, journal = {Am J Respir Cell Mol Biol.}, year = {2014}, volume = {51(5)}, pages = {595-603}, doi = {http://dx.doi.org/10.1165/rcmb.2013-0373TR} }
Shukla A, Gulumian M, Hei TK, Kamp D, Rahman Q, Mossman BT	Multiple roles of oxidants in the pathogenesis of asbestos-induced diseases. [Abstract] [BibTeX]	2003	Free Radic Biol Med. Vol. 34(9), pp. 1117-29	article
Abstract: Exposure to asbestos causes cellular damage, leading to asbestosis, bronchogenic carcinoma, and mesothelioma in humans. The pathogenesis of asbestos-related diseases is complicated and still poorly understood. Studies on animal models and cell cultures have indicated that asbestos fibers generate reactive oxygen and nitrogen species (ROS/RNS) and cause oxidation and/or nitrosylation of proteins and DNA. The ionic state of iron and its ability to be mobilized determine the oxidant-inducing potential of pathogenic iron-containing asbestos types. In addition to their capacity to damage macromolecules, oxidants play important roles in the initiation of numerous signal transduction pathways that are linked to apoptosis, inflammation, and proliferation. There is strong evidence supporting the premise that oxidants contribute to asbestos-induced lung injury; thus, strategies for reducing oxidant stress to pulmonary cells may attenuate the deleterious effects of asbestos.
BibTeX: @article{ShuklaA2003, author = {Shukla A, Gulumian M, Hei TK, Kamp D, Rahman Q, Mossman BT}, title = {Multiple roles of oxidants in the pathogenesis of asbestos-induced diseases.}, journal = {Free Radic Biol Med.}, year = {2003}, volume = {34(9)}, pages = {1117-29} }
Shukla A, Vacek P, Mossman BT	Dose-Response Relationships in Expression of Biomarkers of Cell Proliferation in in vitro Assays and Inhalation Experiments. [Abstract] [BibTeX]	2004	Nonlinearity Biol Toxicol Med. Vol. 2(2), pp. 117-28	article	DOI
Abstract: Asbestos is a group of naturally occurring mineral fibers which are associated in occupational settings with increased risks of malignant mesothelioma (MM), lung cancers, and pulmonary fibrosis (asbestosis). The six recognized types of asbestos fibers (chrysotile, crocidolite, amosite, tremolite, anthophyllite, and actinolite) are different chemically and physically and may have different dose-response relationships in the development of various asbestos-associated diseases. For example, epidemiologic and lung fiber content studies suggest that the pathogenic potential and durability of crocidolite is much greater than chrysotile asbestos in the causation of human MM. We have used isolated mesothelial cells, the target cells of MM, as well as epithelial cells of the lung, the target cells of lung cancers, in vitro to elucidate the dose-response relationships in expression of early response protooncogenes and other genes critical to cell proliferation and malignant transformation in cells exposed to crocidolite and chrysotile asbestos, as well as a number of nonpathogenic fibers and particles. These studies reveal distinct dose-response patterns with different types of asbestos, suggesting a threshold for effects of chrysotile both in in vitro studies and inhalation experiments. The different patterns of gene expression have been confirmed in lungs of rats exposed by inhalation to these types of asbestos. Experiments also suggest no observed adverse effect levels after evaluation of lung injury, inflammation, and fibrosis at lower concentrations of both types of asbestos.
BibTeX: @article{ShuklaA2004, author = {Shukla A, Vacek P, Mossman BT}, title = {Dose-Response Relationships in Expression of Biomarkers of Cell Proliferation in in vitro Assays and Inhalation Experiments.}, journal = {Nonlinearity Biol Toxicol Med.}, year = {2004}, volume = {2(2)}, pages = {117-28}, doi = {http://dx.doi.org/10.1080/15401420490464420} }
Subramanian V, Madhavan N	Asbestos problem in India. [Abstract] [BibTeX]	2005	Lung Cancer. Vol. 49 Suppl 1, pp. S9-12	article	DOI
Abstract: Primary exposure to asbestos in India can be encountered in the form of asbestos mining, asbestos cement industries, asbestos processing unit and during renovation and demolition of old asbestos cemented roof or other structures as well as modern electrical as well as mechanical appliances in which asbestos is still found. Ultimately construction workers, electricians, vehicle mechanics and other workers in the building trades who are exposed to asbestos inhale hundreds and thousands of amphiboles, which causes lung damage. It is being mined in India at places such as Andhra Pradesh (Pulivendla), Jharkand (Roro), Rajasthan (Ajmer, Bhilwara, Udaipur, Rajsamand) and the common problem faced by the locals are asbestosis through air and fluorosis through drinking water. The problem continues to be in India as well as other developing countries. Also, India import and re-export asbestos to other countries and workers at shipyard, transport of the hazardous material on road and roadside residents all are vulnerable to this uncommon disease. The signs and symptoms generally found with the workers are shortness of breath, persistent and productive cough due to pulmonary fibrosis can show up many years after the asbestos exposure.
BibTeX: @article{SubramanianV2005, author = {Subramanian V, Madhavan N}, title = {Asbestos problem in India.}, journal = {Lung Cancer.}, year = {2005}, volume = {49 Suppl 1}, pages = {S9-12}, doi = {http://dx.doi.org/10.1016/j.lungcan.2005.03.003} }
Tiwari RR, Saha A	Knowledge and attitude towards asbestos hazards among asbestos workers in India. [BibTeX]	2015	Int J Occup Environ Med. Vol. 6(1), pp. 58-60	article
BibTeX: @article{TiwariRR2015, author = {Tiwari RR, Saha A}, title = {Knowledge and attitude towards asbestos hazards among asbestos workers in India.}, journal = {Int J Occup Environ Med.}, year = {2015}, volume = {6(1)}, pages = {58-60} }
Upadhyay D, Kamp DW	Asbestos-induced pulmonary toxicity: role of DNA damage and apoptosis. [Abstract] [BibTeX]	2003	Exp Biol Med (Maywood). Vol. 228(6), pp. 650-9	article
Abstract: Asbestos causes asbestosis and various malignancies by mechanisms that are not clearly defined. Here, we review the accumulating evidence showing that asbestos is directly genotoxic by inducing DNA strand breaks (DNA-SB) and apoptosis in relevant lung target cells. Although the exact mechanisms by which asbestos causes DNA damage and apoptosis are not firmly established, some of the implicated mechanisms include the generation of iron-derived reactive oxygen species (ROS) as well as reactive nitrogen species (RNS), alteration in the mitochondrial function, and activation of the death receptor pathway. We focus on the accumulating evidence implicating ROS. DNA repair mechanisms have a key role in limiting the extent of DNA damage. Recent studies show that asbestos activates DNA repair enzymes such as apurinic/apyrimidinic endonuclease (APE) and poly (ADP-ribose) polymerase (PARP). Asbestos-induced neoplastic transformation may result in the setting where DNA damage overwhelms DNA repair in the face of a persistent proliferative signal. Strategies aimed at limiting asbestos-induced oxidative stress may reduce DNA damage and, as such, prevent malignant transformation.
BibTeX: @article{UpadhyayD2003, author = {Upadhyay D, Kamp DW}, title = {Asbestos-induced pulmonary toxicity: role of DNA damage and apoptosis.}, journal = {Exp Biol Med (Maywood).}, year = {2003}, volume = {228(6)}, pages = {650-9} }
Murlidhar V	Occupationally acquired asbestosis in a healthcare worker. [BibTeX]	2015	BMJ Case Rep. Vol. 7(2015)	article
BibTeX: @article{V2015, author = {Murlidhar V}, title = {Occupationally acquired asbestosis in a healthcare worker.}, journal = {BMJ Case Rep.}, year = {2015}, volume = {7}, number = {2015} }
Murlidhar V	Parenchymal asbestosis can lead to lung cancer within a short time frame: more frequent follow-up surveillance is needed than currently recommended. [BibTeX]	2015	BMJ Case Rep. Vol. 15(2015)	article	DOI
BibTeX: @article{V2015a, author = {Murlidhar V}, title = {Parenchymal asbestosis can lead to lung cancer within a short time frame: more frequent follow-up surveillance is needed than currently recommended.}, journal = {BMJ Case Rep.}, year = {2015}, volume = {15}, number = {2015}, doi = {http://dx.doi.org/10.1136/bcr-2015-209425} }
Varkey B, Kumar UN	Asbestos-related diseases of lung and pleura: clinical picture and illustrative cases. [Abstract] [BibTeX]	1978	Postgrad Med. Vol. 63(6), pp. 48-66	article
Abstract: Exposure to asbestos may occur in any of a large number of occupations, and the latent period from exposure to appearance of clinical or roentgenologic evidence of related disease of the lung or pleura, or both, may be more than 20 years. A complete occupational history is therefore of paramount importance in the detection of asbestos-related diseases. Illustrative cases highlight the features of benign and malignant diseases of the lung and pleura for which a causal relationship to asbestos exposure is probable or established.
BibTeX: @article{VarkeyB1978, author = {Varkey B, Kumar UN}, title = {Asbestos-related diseases of lung and pleura: clinical picture and illustrative cases.}, journal = {Postgrad Med.}, year = {1978}, volume = {63(6)}, pages = {48-66} }
Verma DK, Purdham JT, Roels HA	Translating evidence about occupational conditions into strategies for prevention. [BibTeX]	2002	Occup Environ Med. Vol. 59(3), pp. 205-13	article
BibTeX: @article{VermaDK2002, author = {Verma DK, Purdham JT, Roels HA}, title = {Translating evidence about occupational conditions into strategies for prevention.}, journal = {Occup Environ Med.}, year = {2002}, volume = {59(3)}, pages = {205-13} }
Viswanathan PN, Dogra RK, Shanker R, Zaidi SH	Pulmonary fibrogenic response of guinea pigs to amosite dust. [BibTeX]	1973	Int Arch Arbeitsmed. Vol. 31(1), pp. 51-9	article
BibTeX: @article{ViswanathanPN1973, author = {Viswanathan PN, Dogra RK, Shanker R, Zaidi SH}, title = {Pulmonary fibrogenic response of guinea pigs to amosite dust.}, journal = {Int Arch Arbeitsmed.}, year = {1973}, volume = {31(1)}, pages = {51-9} }
Zaidi SH, Bhattacherjee JW, Dogra RK, Saxena RP	Effect of BCG on experimental asbestosis. [BibTeX]	1982	Ind Health. Vol. 20(2), pp. 129-37	article
BibTeX: @article{ZaidiSH1982, author = {Zaidi SH, Bhattacherjee JW, Dogra RK, Saxena RP}, title = {Effect of BCG on experimental asbestosis.}, journal = {Ind Health.}, year = {1982}, volume = {20(2)}, pages = {129-37} }